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Shannon M. Conley, Moore, OK
Two Blind Mice and a Wild-Type
Knockout and knockin mice are genetically engineered to carry mutations in their genome to model debilitating diseases, critical since it is difficult to study many diseases in human patients. The scientific and medical advancements that have resulted from use of these models cannot be overstated. This quilt re-interprets my fluorescein angiograms- -pictures of the blood vessels in the eye-- from mice with diabetic retinopathy (top) and macular dystrophy (bottom), as well as their normal or wild-type counterpart (middle). We use these specialized mice to study the pathobiological mechanisms associated with these blinding retinal degenerations and to develop and test novel treatments. $500
Vicki Conley, Ruidoso Downs, NM,
Opium Poppy The beautiful poppy, Papaver somnifermum produces the powerful drug opium and its many derivatives including morphine, codeine, oxycodone, and heroin. Physicians during the Greek and Roman times used opium as an analgesic, as a sedative and to treat cramping and diarrhea. Opiates are such effective therapeutics that they remain first line treatments for pain. Friedrich Serturner isolated morphine from the poppy in the early nineteenth century. This was the first isolation of an active ingredient from a plant and in 1827 Merck began commercially producing it. The Greek god of dreams, Morpheus, inspired Serturner’s original name morphium. $300

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